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Rod Hill, Associate Professor, Physiology
Education
PhD-- Physiology, Central Queensland University, Australia
MS-- Immunology, University of Queensland, Australia
BS--Applied Science, Central Queensland University, Australia
Professional
Experience Physiologist, Department of Animal and Veterinary Science, University of Idaho. 2001-Present.
Scientist
and Project Leader (Growth Physiology) Agency for Food and Fibre
Sciences,
Positions and Responsibilities Physiologist, Department of Animal and Veterinary Science
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Research
Program Program
Aims: To identify and understand of the cellular and molecular
mechanisms underlying muscle and adipose tissue growth and
differentiation, and their manipulation to improve production
efficiency. 1.
Leptin – insulin interaction – Implications for energy expenditure
and production efficiency. Leptin
inhibits insulin-mediated lipogenesis in adipose tissue and promotes
utilization of free fatty acids by muscle. Leptin also attenuates
insulin-mediated reduction of free fatty acid oxidation in muscle.
Thus, leptin appears to directly modulate an normal array of insulin
actions, particularly those associated with the storage and utilization
of lipids and free fatty acids. This interaction is important in
over the longer term. It is controlling basal metabolism and of
long-term energy storage and utilization. The mechanism of
interaction between leptin and insulin is being studied from the
molecular through to the whole animal level. Intracellular
mechanisms are being studied using a range of models. An important aspect of this program is interaction with
other scientists throughout the The
IGFs are potent stimulators of muscle growth, and are essential for
normal growth and development. Treatment with IGF-1 improves
protein acretion by inhibiting breakdown. This has major
significance for manipulation of muscle growth and fat deposition. The implication is that domestic animals could be
managed to be more metabolically efficient, producing more muscle tissue
for an equivalent food intake. There are also extensive potential
benefits of these findings in clinical treatment of obesity, muscular
diseases, catabolic states such as diabetes, cancer cachexia, and peri-operative
stress in humans. Current investigations focus upon the modulation
of IGF actions by IGF-binding proteins. National and international
collaboration is also a feature of this program.
Polyacrylamide gel electrophoresis (PAGE). PAGE has proved to be a powerful method used as a component during a protein purification regimen or when characterizing purified proteins. The procedure involves placing a protein into an electric field. Due to the charged nature of the protein, it will migrate towards the electrode of the opposite charge.
Publications, Exhibitions, Performances, Recitals: Refereed/Adjudicated Journals: 22. Baker, S.D., Szasz, J.I., Klein, T.A., Kuber, P.S., Hunt, C.W., Glaze, Jr., J.B., Falk, D., Richard, R., Miller, J.C., Battaglia, R.A., and Hill, R.A. (2006). Residual Feed Intake of Purebred Angus Steers: Effects on Meat Quality and Palatability. Journal of Animal Science 84:938-945. 21. Strat, A.L., Kokta, T.A., Dodson, M.V., Gertler, A., Wu, Z. and Hill, R.A. (2005). Early Signaling Interactions between the Insulin and Leptin Pathways in Bovine Myogenic Cells. Biochimica et Biophysica Acta 1744:165-174. 20. Fernyhough, M.E., Helterline, D.L., Vierck, J.L., Hausman, G.J., Hill, R.A. and Dodson, M.V.(2005). Dedifferentiation of mature adipocytes to form adipofibroblasts:1. More than just a possibility. Adipocytes 1:17-24. 19. Kinkel, A.D., Fernyhough, M.E., Helterline, D.L., Vierck, J.L., Hausman, G.J., Hill, R.A., and Dodson, M.V. (2005). Oil red-O stains non-adipogenic cells: A precautionary note. Cytotechnology. 46:1-8. 18. Hill, R.A., Strat, A.L., Hughes, N.J., Cochrane, J., Dodson, M.V., and Gertler, A. (2004). The Insulin Signaling Cascade In A Non-Pathological Model of Insulin Resistance: The Bovine Myogenic Cell and an Insulin-Sensitive Model: Mouse Sol8 Cell Line. Biochimica et Biophysica Acta 1693:205-211. 17. Fernyhough, M.E., Helterline, D.L., Vierck, J.L., Hill, R.A. and Dodson, M.V. (2004). Coulter Counter use in the enumeration of muscle and fat stem cells. Methods in Cell Science 25(3-4):221-225. 16. Kokta, T.A., Dodson, M.V., Gertler, A. and Hill, R.A. (2004). Intercellular Signaling Between Adipose Tissue and Muscle Tissue. Domestic Animal Endocrinology. 27:301-331. 15. Hendricksen, R.E., Gazzola, C., Reich, M.M., Roberton, R.F., Reid, D.J., and Hill, R.A. (2003) Using molasses as an alternative to controlled release devices for administering n-alkane markers to cattle Animal Science 76:471-480. 14. Margetic, S., Gazzola, C., Pegg, G.G. and Hill, R.A. (2002) Leptin: a review of its peripheral actions and interactions. International Journal of Obesity and Related Metabolic Disorders 26:1407-1433 13. Margetic, S., Gazzola, C., Pegg, G.G. and Hill, R.A. (2002) Characterisation of leptin binding in bovine kidney membranes. Domestic Animal Endocrinology. 23: 411-424. 12. Gazzola, C., Jeffery, M.R., White, D.H., Hill, R.A. and Reid, D.J. (2002) Effect of delayed castration on growth rate, behaviour and serum insulin-like growth factor-1 concentration on beef cattle on tropical pasture. Animal Science 75: 41-47. 11. Hendricksen, R.E., Reich, M.M., Roberton, R.F., Reid, D.J., Gazzola, C., Rideout, J.A. and Hill, R.A. (2002) Predicting the voluntary intake and digestibility of tropical pasture hays using alkanes Animal Science 74:567-577. 10. Gazzola, C., Jeffery, M.R., White, D.H., Hill, R.A. and Reid, D.J. (2001) Effect of age of castration, oestradiol treatment and genotype on the fat colour of pasture-fed beef cattle. Animal Science 73: 261-266. 9. Pell, J.M., Hill, R.A., Stewart C.E.H., Weston, C.R., and Flick-Smith, H.C. (2000) Enhancement of IGF-I activity by novel antisera: potential structure/function interactions. Endocrinology 141: 741-751. 8. Hill, R.A., Hunter, R.A., Lindsay, D.B., and Owens, P.C. (1999) Action of Long (R3)-IGF-1 on protein metabolism in beef heifers. Domestic Animal Endocrinology 16: 219-229. 7. Hill, R.A., Margetic, S., Pegg, G.G. and Gazzola, C. (1998) Leptin: its pharmacokinetics and tissue distribution. International Journal of Obesity 22: 765-770. 6. Hill, R.A., Hoey, A.J., and Sillence, M.N. (1998) Functional activity of antibodies at the bovine b2-adrenoceptor. Journal of Animal Science 76: 1651-1661. 5. Hill, R.A. and Pell, J.M. (1998) Regulation of Insulin-Like Growth Factor I (IGF-I) Bioactivity in Vivo: Further Characterization of an IGF-I-Enhancing Antibody. Endocrinology 139: 1278-1287. 4. Hill, R.A., Flick-Smith, H.C., Dye, S., and Pell, J.M. (1997) Actions of an IGF-1 enhancing antibody on IGF-1 pharmacokinetics and tissue distribution: increased IGF-1 bioavailability Journal of Endocrinology 152: 123-130. 3. Hill, R.A. and Sillence, M.N. (1997) Improved membrane isolation in the purification of b2-adrenoceptors from transgenic Escherichia coli. Protein Expression and Purification 10: 162-167. 2. Pell, J.M., Flick-Smith H.C., Dye, S. and Hill, R.A. (1995) Further characterization of an IGF-1 enhancing antibody: actions on IGF-induced hypoglycaemia and interaction with the analogue LR3IGF-1. Progress in Growth Factor Research 6: 367-75. 1. Hill, R.A. and Cook, D.R. (1994) Protein profiles of Brucella suis and Brucella abortus in isoelectric focusing and sodium-dodecyl sulphate polyacrylamide gel electrophoresis. Veterinary Microbiology. 39:25-32. Refereed Proceedings: Hill, R.A. and Herd, R.M. (2001) Variation in the endocrine system which might affect feed efficiency. In (Archer, J.A., Herd, R.M. and Arthur, P.F. eds) Feed Efficiency in Beef Cattle, Proceedings of the Feed Efficiency Workshop, Cooperative Research Centre for Cattle and Beef Quality. Armidale. Australia. pp 46-50. Hill, R.A. (1992) Immunological manipulation of growth in cattle Proc. UCQ PostGrad.Stud.Assn., 1:13-17. Book Chapters: Hill, R.A.(2004). The Role of the Leptin Axis in Modulating Enery Partitioning and Nutrient Utilization in Livestock Species. In: Garnsworthy, P.C., and Wiseman, J. (eds.) Recent Advances in Animal Nutrition. Nottingham University Press. Sutton Bonington. U.K. (in press). Hill, R.A., Pell, J.M. and Flint, D.J. (2003) Immunomodulation of Growth. In: Biology of Growth of Domestic Animals. Chapter 18. Colin G. Scanes (Ed). Iowa State Press. Hill, R.A., Dunshea, F.R. and Dodson, M.V. (2003) Growth and Livestock. In: Biology of Growth of Domestic Animals. Chapter 19. Colin G. Scanes (Ed). Iowa State Press. Editorials Hill, RA. (2003). Leptin quantification: On the steep part of the learning curve. Animal Science 76: 1-2. Other: Hill R., Holmes, M., and Smith, N. (1997). Growth promoting properties of antibodies with activity at the insulin-like growth factor-1 (IGF-1) axis. In Loxton, I. and Boadle, R. (eds.) Brigalow Research Station Technical Report 1996 Department of Primary Industries Queensland. Professional Meeting Papers, Workshops, Showings, Recitals: Invited Presentations 2005 Hill, R.A., Baker, S.D., Klein, T.A., Szasz, J.I., Ahola, J.K., Hristov, A.N, Price, W., Huhtanen, P. and Sariola, J. (2005). Net Feed Efficiency: Possibilities for the Future. Pacific Northwest Animal Nutrition Conference. pp 199-210. Hill, R.A.(2005). Fat Mice, Muscle Men and the Supersize Culture. Human Nutrition, Food and Animal Sciences, University of Hawaii at Manoa. June 30. Hill, R.A.(2005). Leptin-Insulin Axis Cross-talk in a Bovine Myogenic Cell Model, Charles Sturt University, Wagga Wagga, Australia. June 28. 2004 Hill, R.A.(2004). Leptin Axis: Regulation of Enery Substrate Partitioning in Ruminants. Department of Animal Sciences, Purdue University. November 16. Hill, R.A. (2004). The Role of the Lepting Axis in Modulating Enery Partitioning and Nutrient Utilization in Livestock Species. The 38th Nottingham Feed Conference. University of Nottingham. Sutton Bonington. U.K. September 14-16. Conference Articles: 40. Choi, J.M., Papasani, M.R., and Hill, R.A.(2006). Effect of linoleic and oleic acids on lipid accumulation and adipogenesis in 3T3-L1 cells. The Endocrine Society's 88th Annual Meeting, (accepted). 39. Papasani, M.R., Robison, B.D., Hardy, R.W., and Hill, R.A. (2006). Temporal and spatial expression of two zebrafish insulin genes during early development. The Endocrine Society's 88th Annual Meeting, (accepted). 38. Amberg, J.J., Papasani, M.R., Cook, M.A., Hardy, R.W., Rust, M.B., Anderson, C.L., and Hill, R.A. (2006). An intestinal peptide transporter, pept1-like, identified in altricial larval fishes: beginning to understand the importance of intestinal peptide uptake in larval fishes. World Aquaculture Society Meeeting, Las Vegas, NV. 37. Papasani, M.R., Kokta, T.A., Strat, A.L., Gertler, A. and Hill, R.A. (2005). Regulation of gene expression in Sol8 myogenic cells in response to leptin. The Endocrine Society's 87th Annual Meeting. 36. Kokta, T.A., Strat, A.L., Papasani, M.R., Szasz, J.I., Dodson, M.V., and Hill, R.A. (2005). Regulation of Lipid Accumulation in 3T3-L1 cells: effects of Oleic and Linoleic Acids and Insulin. The Endocrine Society's 87th Annual Meeting, (accepted). 35. Szasz, J.I., Hunt, C.W., Baker, S.D., Klein, T., Kuber, P.S., Glaze, B., Falk, D., Richard, R., Miller, J., Battaglia, R.A., and Hill, R.A. (2004) Correlations among ultrasonic carcass estimates, growth performance measures, and residual feed intake in Angus steers. Journal of Animal Science 82 (supplement 1) 409. 34. Kokta, T.A., Strat, A.L., Dodson, M.V., Gertler, A. and Hill, R.A. (2004). Preliminary Characterization of Differentiating Bovine Adipofibroblasts. Proceedings of the Endocrine Society, A163. 33. Strat, A.L., Dodson, M.V., Gertler, A., and Hill, R.A. (2004) Leptin-Insulin Interactions: Effects on Insulin Receptor Substrate-1 Modulation in Bovine Myogenic Cells. Proceedings of the Endocrine Society A473. 32. Strat, A.L., Rodgers, B.D., Dodson, M.V., Gertler, A., and Hill, R.A. (2004). Leptin Induced or Suppressed Genes in Myogenic Cells using High-Density Oligonucleotide Arrays. Diabetes 53: (supplement 2) 267. 31. Strat, A.L., Holder, M.C., Wallace, A., Dodson, M.V., Gertler, A. and Hill, R.A. (2003). Models of Insulin Resistance: Towards Defining Pathological Changes in the Insulin Signaling Cascade. 4th Annual Rachmiel Levine Diabetes and Obesity Symposium. p.112. City of Hope CA.. 30. Cochrane, J., Strat, A.L., Dodson, M.V., Gertler, A. and Hill, R.A. (2003). The Impact of Serine Phosphorylation on the Insulin Pathway. Proceedings of the American Chemical Society 143:93. 29. Hunt, M.L., Kokta, T.A., O’Shea, T., Hill, R.A. and McFarlane, J.R. (2003) Leptin clearance rates during the early follicular phase are higher than during the luteal phase of the estrius cycle in ewes. Proceedings of the Endocrine Society of Australia. 46: 77. 28. Hill, R.A., Dodson, M.V., Gertler, A., Hughes, N.J. and Henderson, D. (2003). Insulin signaling in bovine myogenic cells. Journal of Animal Science 81(supplement 1): 96. 27. Hill, R.A., Margetic, S. and Hughes, N. (2002). Leptin binding moieties in bovine serum. Journal of Animal Science. 80 (supplement 1): 195. 26. Margetic, S., Pegg, G.G., Johnson, P., Gazzola, C. and Hill, R.A. (2000). Leptin receptor expression in rat peripheral tissues. 11th International Congress of Endocrinology, Sydney p227. 25. Margetic, S., Qui, X.Y., Pegg, G.G., D’Occhio, M.J., Gazzola, C. and Hill, R.A. (2000). Effect of mouse leptin on angiogenesis. 15th Australasian Biotechnology Conference, p79. 24. Hill, R.A., Roberton, R.F., and Reid, D.J. (2000) Vaccination with an insulin-like growth factor binding protein-1 (IGFBP-1)-based vaccine improves growth in feed-restricted steers. Asian-Australasian Journal of Animal Sciences 13 Supplement B: 240. 23. Smith, N.N., Hill, R.A., Pegg, G.G., and Pell, J.M. (2000) Passive immunization with anti-IGF-1 antibodies increases feed intake during nutritional restriction. Asian-Australasian Journal of Animal Sciences 13 Supplement C: 154. 22. O’Neill, C.J., Reid, D.J., Kelly, M.J., and Hill, R.A. (2000) Variation in calving success in a Brahman herd in northern Australia. Asian-Australasian Journal of Animal Sciences 13 Supplement B: 150. 21. Reich, M.M., Hendricksen, R.E., Rideout, J.A., Gazzola, C., and Hill, R.A. (2000) Alkane profiles in tropical forages. Asian-Australasian Journal of Animal Sciences 13 Supplement B: 152. 20. Hendricksen, R.E., Reich, M.M, Roberton, R.F., Rideout, J.A., Reid, D.J., Gazzola, C., and Hill, R.A. (2000) Using alkanes to predict voluntary intake, faecal output and digestibility of buffel grass hay fed to steers. Asian-Australasian Journal of Animal Sciences 13 Supplement B: 148. 19. Gazzola, C., White, D.H., Hendricksen, R.E., Hill, R.A., and Roberton, R. F. (2000) The performance of chromium and ytterbium intraruminal controlled release devices in beef cattle. Asian-Australasian Journal of Animal Sciences 13 Supplement B: 147. 18. Gazzola, C., Hill, R.A., Jeffery, M.R., O’Neill, C.J., Reid, D.J., White, D.H., and Burns, B.M. (2000) Scrotal circumference at puberty and its relationship to testes mass in three genotypes of beef cattle. Asian-Australasian Journal of Animal Sciences 13 Supplement B: 146. 17. Hill, R.A. (1999) Putative membrane-associated high affinity binding site for insulin-like growth factor-1. Proceedings Endocrine Society of Australia. 42: 68. 16. Margetic, S., Hill, R.A., Pegg, G.G., and Gazzola, C. (1999) Characterisation of leptin receptors in bovine kidney using radioligand binding techniques. Proceedings Endocrine Society of Australia. 42: 77. 15. Smith, N.N. and Hill, R.A. (1999) Binding characterisation of anti-insulin-like growth factor-1 (IGF-1) antibodies raised in cattle and sheep. Proceedings Endocrine Society of Australia. 42: 73. 14. Hill, R.A., Gazzola, C., Herd, R.M., and Oddy, V.H. (1998) An insulin-like growth factor-1 based vaccine changes body composition in Angus steers. Proc. Nutrn. Soc. Aust. 22: 176. 13. Gazzola, C., Hill, R.A., Herd, R.M. and Oddy, V.H. (1998) Effect of immunization against leptin on growth rate and fat deposition in cattle. Proc. Nutrn. Soc. Aust. 22: 94. 12. Hill, R.A., Smith, N.N., and Holmes, M.A. (1998) An Insulin-like Growth Factor-1 based vaccine improves growth rate in steers. Anim. Prod Aust. 22: 321. 11. O’Neill, C.J., Weldon, G.J., Hill, R.A., and Thomas, J. (1998) Adaptaur Association of Australia: A breed association based on the performance recording of Adaptaur Cattle. Anim. Prod Aust. 22: 229. 10. Margetic, S., Hill, R.A., Pegg, G.G., and Gazzola, C. (1998) Characterisation of leptin binding proteins in bovine serum. Proceedings Endocrine Society of Australia. 41: 75. 9. Hill, R.A. Margetic, S., Pegg, G.G., and Gazzola, C. (1997) Leptin pharmacokinetics and binding in plasma of female rats. Proceedings Endocrine Society of Australia. 40:94 8. Margetic, S., Hill, R.A., Pegg, G.G., and Gazzola, C. (1997) Dietary restriction does not affect serum leptin concentration or tissue distribution of leptin in female rats. Proceedings Endocrine Society of Australia. 40:93. 7. Hill, R.A. and Sillence, M.N. (1996) Humoral immune response against a potential auto-antigen: the b2-adrenoceptor. First FIMSA Conference, Adelaide. 6. Smith, N.N., Holmes, M.A., and Hill, R.A. (1996) Characterization of anti-Insulin-Like Growth Factor-1 (IGF-1) antibodies raised in cattle and sheep. First FIMSA Conference, Adelaide. 5. Pell, J.M., Flick-Smith, H.C., Stewart, C.E.H. and Hill, R.A. (1996) Localization of a major binding site on IGF-1 for an IGF-1 enhancing antibody. 10th International Congress of Endocrinology, San Francisco, CA (Abstract P1-547). 4. Pell, J.M., Hill, R.A., Dye, S., and Flick-Smith, H.C. (1996) Further characterization of an IGF-1 enhancing antibody. Journal of Endocrinology 148(suppl.): p96. 3. Pell, J.M., Flick-Smith, H., Stewart, C.E.H., and Hill, R.A. (1996) Peptide mimics for a major binding site on IGF-1 for an IGF-1 enhancing antibody. Journal of Endocrinology 151(suppl.):p32. 2. Hill, R.A., Dye, S., Sheldrick, E.L., Flick-Smith, H.C. and Pell, J.M. (1995) Regulation of plasma clearance and tissue distribution of Insulin-Like Growth Factor-1 (IGF-1) by an IGF-1 enhancing antibody. Journal of Endocrinology 144(suppl.):p63. 1. Pell, J.M. and Hill, R.A. (1995) IGF-1 enhancing antibody: actions on IGF-1 clearance and IGF-1-induced hypoglycaemia and interaction with the analogue LR-IGF-1. 4th International Congress on IGFs. Miami, Florida. NCBI-GeneBank Submissions Papasani, M.R., Robison, B.D., Hardy, R.W., and Hill, R.A. (2005). Expression of zebrafish insulin-2, 498 bp mRNA linear. Accession No. DQ156497, submitted. Patents: Hill, R.A. and Sillence, M.N. 1995 Australian Patent Application No. PM9972. Hill, R.A. and Sillence, M.N. 1994 Australian Patent Application No. PM7084. Note: The right to publish all work associated with these patent applications was delayed. Publication of this work began in 1997. This includes all of the work of my Ph.D. Thesis. Outreach Presentations: Hill, R.A.(2003). Feed Efficiency in Beef Cattle - What's in it for the Cattleman? North Idaho Cattlemen's Meeting. October, Coeur d'Alene. Leadership Presentations 2005: Hill, R.A. Leadership Idaho Agriculture from a Participant's Viewpoint, Moscow, ID. April 2005. 2004: Hill, R.A. et al. Leadership Idaho Agriculture, Boise, ID. Debate Adjudication Panel, February, 2004. Professional and Scholarly Organizations
AVS221-Biol212 Course Site Chromatin
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